Salusin-β is superior to salusin-α as a marker for evaluating coronary atherosclerosis
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چکیده
منابع مشابه
Roles of Dermcidin, Salusin-α, Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis
Background:Brucella spp. are facultative intracellular pathogens that can cause chronic infections in many tissues and organs. Objectives: To investigate serum dermcidin, salusin-alpha, salusin-beta and TNF-alpha levels and their correlation with each other in patients with acute brucellosis. Methods: From 50 patients hospitalized upon...
متن کاملSalusin-β as a powerful endogenous antidipsogenic neuropeptide.
Salusin-β is an endogenous parasympathomimetic peptide, predominantly localized to the hypothalamus and posterior pituitary. Subcutaneously administered salusin-β (50 nmol/mouse) significantly increased water intake but did not affect locomotor activity or food intake. The salusin-β-induced increase in water intake was completely abrogated by pretreatment with muscarinic antagonist, atropine su...
متن کاملSalusin-β Not Salusin-α Promotes Vascular Inflammation in ApoE-Deficient Mice via the I-κBα/NF-κB Pathway
OBJECTIVE Vascular inflammation plays an important role in the development and progression of atherosclerosis. Recently, salusins (salusin-α and salusin-β) have been reported to be associated wtih atherosclerosis. However, its underlying mechanism remains incompletely known. In this study, we observed the effects of salusins on vascular inflammation in apoE-deficient (apoE-/-) mice. METHODS A...
متن کاملSalusins: Potential Use as a Biomarker for Atherosclerotic Cardiovascular Diseases
Human salusin- α and salusin- β are related peptides produced from prosalusin. Bolus injection of salusin- β into rats induces more profound hypotension and bradycardia than salusin- α . Central administration of salusin- β increases blood pressure via release of norepinephrine and arginine-vasopressin. Circulating levels of salusin- α and salusin- β are lower in patients with essential hyperte...
متن کاملSalusin-β, but Not Salusin-α, Promotes Human Umbilical Vein Endothelial Cell Inflammation via the p38 MAPK/JNK-NF-κB Pathway
OBJECTIVE Recently, salusin-β has been reported to have pro-atherosclerotic effects, but salusin-α has anti-atherosclerotic effects. Our previous study has shown that salusin-β but not salusin-α promotes vascular inflammation in apoE-deficient mice. However, the underlying mechanism remains unknown. In this study, we observed the effect of salusins on inflammatory responses and the MAPK-NF-κB s...
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ژورنال
عنوان ژورنال: Journal of International Medical Research
سال: 2020
ISSN: 0300-0605,1473-2300
DOI: 10.1177/0300060520903868